The Methodist Hospital - Research Institute Cohort

The Methodist Hospital-Research Institute

Department of Obstetrics and Gynecology
6550 Fannin, Suite 901
Houston, Texas 77030
Telephone: (713) 441-3198
Contact: Dana Ambriz






About the study:

In 1971, the development of clear cell adenocarcinoma of the vagina and cervix in young women were linked to in-utero exposure to Diethylstilbestrol (DES). In 1974, The National Cancer Institute issued a request for proposal to study the problem of cancer detection and prevention in DES-exposed offspring through identification and examination of DES-exposed men and women. Approximately 1435 participants were enrolled into the Baylor DESAD Study.

Prenatal records of physicians and clinics willing to participate in the project were reviewed for identification of pregnancies in which DES was prescribed. These records were linked to delivery data to accomplish identification of live births. Subsets of both exposed and unexposed daughter were “matched”. Participants were also enrolled from women seeking “DES examinations” (walk-in) or from referrals by physician, only if prenatal records documenting exposure to DES were available. Prenatal records from the same sources that indicated no exposure to hormonal medications became the basis for identification of “control” subjects. In 2010, funding was once again awarded in order to obtain current health information from the daughters who participate in the DES Follow-up Study. Sons are not followed at this center.

About the Research Team:

Christopher Hobday M.D.,, joined the Department of Obstetrics and Gynecology at the Methodist Hospital in 2008 and is currently the director of the Raymond H. Kaufman Dysplasia Clinic. He is a also member of The Methodist Hospital Research Institute. As a member of the Clinical Faculty at The Methodist Hospital he is actively involved in resident teaching and research. Dr. Hobday completed his medical degree at the University of North Carolina at Chapel Hill and his residency at the University of Texas-Houston in the Lyndon Baines Johnson Obstetrics and Gynecology Residency Program.

Ervin Adam, M.D., Has served as professor of the Department of Molecular Virology & Microbiology and in the department of Obstetrics and Gynecology at Baylor College of Medicine. Dr. Adam has been a faculty member for over 40 years. As an Epidemiologist, he has been instrumental in establishing the procedures for data analysis and data storage for the original DESAD project and the current DES Follow-up Study. He has published many research articles in peer review journals. Dr. Adam continues his involvement as Sub-Contractor with The Methodist Hospital-Research Institute.

Jaya Kamath, MS, CCRC is the Clinical Trials Manager for the Department of Obstetrics and Gynecology at the Methodist Hospital. Ms. Kamath is responsible for daily management, and supervision of accumulated data collection for the study.

Carolyn B. Alexander, R.N. was a staff member of Baylor College of Medicine De-partment of Obstetrics and gynecology for 31 years, and served as research nurse for the original DESAD study. She continues this roll at The Methodist Hospital – Research Institute. She is primarily responsible for the review and abstraction of medical records received for participants.