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The Dartmouth CohortDartmouth

Dartmouth-Hitchcock Medical Center
Rubin Building, 8th Floor
One Medical Center Drive, HB 7926
Lebanon, NH 03756
Phone number: 603-653-3699/877-295-0030 (toll free)
Email: Linda.Titus-Ernstoff@Dartmouth.edu
          Suzanne.B.Lenz@Hitchcock.ORG
Contact persons: Linda Titus-Ernstoff
                            Suzanne Lenz

 

 

 

 

 

About the Study:

The overall goal of the DES Follow-up Study is to keep track of the health outcomes in three generations: the DES-exposed and unexposed mothers, their children, and their granddaughters. To accomplish this goal, study participants are contacted regularly by mail and asked to complete questionnaires. Through the questionnaires, we identify possible conditions or outcomes that may be associated with DES use. If a diagnosis of interest is reported by a study participant, we ask permission to obtain medical records to confirm the diagnosis. The confidentiality of information obtained from study participants is protected under the full extent of the law.

Mothers Study

The Dartmouth Mothers Study consists of mothers who participated in the Women's Health Study, a follow-up study that originated at Dartmouth in the late 1970’s. The original Women’s Health Study enrolled mothers who gave birth between 1940 and 1960 at one of several collaborating hospitals or clinics. Since 1992, the Dartmouth Study Center has been responsible for following the cohort of women who gave birth at Mary Hitchcock Memorial Hospital or at a private practice in Portland, Maine. Other Women’s Health Study participants were followed by colleagues in Boston.

Sons and Daughters Study

The Dartmouth Study Center regularly contacts the children born to the women who participated in Dartmouth’s Mothers Study. These are the sons and daughters, whether DES-exposed or not, whose mothers gave birth between 1940 and 1960 at Mary Hitchcock Hospital or the private practice in Portland, Maine.

The Granddaughters Cohort

The Dartmouth Study Center also follows the granddaughters of the women who participated in the Dartmouth Mothers Study. All five of the collaborating Study Centers have contributed granddaughters to this study, which we call the Third Generation Study. At each Study Center, the study participants were identified and located with the permission of their mothers. The Dartmouth Study Center is responsible for the planning, coordination, and statistical analyses of the Third Generation Study. This study has just begun, so only one questionnaire has been sent so far.

About the Research Team:

Principal Investigator Linda Titus-Ernstoff, PhD, Professor of Community and Family Medicine at Dartmouth Medical School, specializes in women's health studies, with a particular focus on breast and ovarian cancers. She has studied breast cancer risk in the DES mothers group, psychosexual outcomes in the DES sons and daughters, and reproductive and genitourinary outcomes in the DES sons. Dr. Titus-Ernstoff also leads the NCI’s DES Follow-up Third Generation Study.

Study Coordinator, Suzanne Lenz, M.A. - CCRC, has 18 years of experience as a clinical audiologist and has spent eight years coordinating clinical trials at Dartmouth-Hitchcock Medical Center.

Judith Harjes, the Senior Programmer, has worked with Dr. Titus-Ernstoff on Dartmouth’s DES Follow-up Study since it began in 1992.

Jennifer Gibson-Chambers, the Senior Analyst, works closely with Dr. Titus-Ernstoff on analyses of the third generation study.